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Ubiquitin-proteasome Proteolytic System, The: From Classical Biochemistry To Human Diseases
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Ubiquitin-proteosome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory. This text tells the story of the ubiquitin system as we know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteosome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.
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