Chemistry and Biology of Nitroxyl (HNO)

The Chemistry and Biology of Nitroxyl (HNO) provides the first-of-its-kind coverage of this biologically active molecule with a focus on the study of nitroxyl, also known as azanone per IUPAC nomenclature which has been traditionally elusive due to its intrinsically high reactivity. This comprehensive resource presents the scientific basis to understand the chemistry, along with the technical aspects, of working with the compound. By building on two decades of nitric oxide and nitroxyl research, this book is an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical), biology (molecular, cellular, physiological, and enzymology), pharmacy, and medicine. Through a comprehensive examination that begins by exploring the unique molecule’s structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, and then discussing sources of nitroxyl, this useful resource explores both methods for trapping as well as detecting nitroxyl via spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound’s foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. Presents the first book on HNO (Nitroxyl or Azanone), an increasingly important molecule in biochemistry and pharmaceutical researchProvides a valuable coverage of HNO’s chemical structure and significant reactions, including practical guidance on working with this highly reactive moleculeContains high quality content from recognized experts in both industry and academia