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Preliminary: This study describes a global assessment of stem cell engineering research, achieved through site visits by a panel of experts to leading institutes, followed by dedicated workshops. The assessment made clear that engineers and the engineering approach with its quantitative, system-based thinking can contribute much to the progress of stem cell engineering research. Additionally, the increased need for complex computational models and new, innovative technologies, such as high-throughput screening techniques, organ-on-a-chip models and in vitro tumor models requires an increasing involvement of engineering and physical scientists. Additionally, this book will show that although the US is still in a leadership position in stem cell engineering, Asian countries like Japan, China and Korea, as well as European countries like the UK, Germany, Sweden and the Netherlands are rapidly expanding their investments in the field. Strategic partnerships between countries could lead to major advances of the field and scalable expansion and differentiation of stem cells This study was funded by the National Science Foundation (NSF), the National Cancer Institute (NIH) and the National Institute for Standards and Technology (NIST).