Standardization & Evaluation of laxative activity of 'Dindayal Churna'

The challenges faced by herbal formulations because of their lack of standardization. For evaluation of Churnas containing different herb parameters tested for raw material were organoleptic, physicochemical, physical, phytochemical etc. Parameters for finished product include pH, loss on drying, angle of repose, Carr s index, Hausner s ratio etc. HPTLC fingerprinting of Dindayal and Developed Churna were carried out as a part of evaluation. Dindayal and Developed Churna consist of C. angustifolia leaves and fruits of F. vulgare, T. ammi and T. chebula and it is used as a laxative. Results indicated that raw material of Dindayal and Developed Churna had passed through all organoleptic, physicochemical, physical, and phytochemical parameters. All three batches of Dindayal and Developed Churna were almost uniform. HPTLC fingerprinting indicated presence of peaks at Rf in respective solvent system were matched with Raw material, Dindayal and Developed Churna confirming the presence of raw material in Dindayal Churna as well as Developed churna. Laxative activity of Dindayal Churna was not in dose dependent manner While Developed Churna shown laxative activity in dose dependent manner.