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Solubility Enhancement Of Simvastatin By Using Surfactant HPMC
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Today, 35-40% of all new chemical entities suffer from poor aqueous solubility; hence the enhancement of the solubility of poorly water-soluble drug is one of the most challenging aspects of modern drug development. The aqueous solubility of a drug is an important molecular property that mainly influences the extent of its oral bioavailability. Due to their poor aqueous solubility many drug candidates became unsuccessful to reach in the market in spite of exhibiting potential pharmacodynamic properties. Therefore it is very useful to find appropriate formulation approach to improve aqueous solubility and thus bioavailability of poorly soluble drug. Poor bioavailability may also oblige the formulator to choose the injection route instead of the oral route. Injection route is costly. For good oral bioavailability drug must be soluble in gastro-intestinal fluids i.e. aqueous soluble and also possess permeability properties for good membrane diffusion in order to reach the bloodstream
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