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This book is the proceedings of the Tenth International Symposium on Purine and Pyrimidine Metabolism in Man. Articles included contain new data concerning the various aspects of purine and pyrimidine in man. The main topics covered are: normal metabolism of purines and pyrimidines; the inborn errors of purine and pyrimidine metabolism; purinergic signaling; chemotherapy with purine and pyrimidine analogues, renal handling of purines and some methodological approaches for the study of the various aspects of purine and pyrimidine metabolism.