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The effect of calciumantagonists on the kidney is to a large extent unknown. Preliminary results of physiological investigations indicate that calcium antagonists influence the canals in the distal part of the tubule and the influx of calcium. Experimental investigations on different models in nephrocalcinosis point to the effect of this group of substances as protectives in acute renal failure, and also to a possible application in renal transplantation and urolithiasis.