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The prevalence of the metabolic syndrome increases after the onset of menopause, and may explain in part the apparent acceleration of cardiovascular disease in postmenopausal women.The objectives of this study is to determine the prevalence of metabolic syndrome among postmenopausal women and its associated factors at Gynaecology clinic Hospital Universiti Sains Malaysia.This is a cross sectional study involving 411 women and metabolic syndrome was defined in accordance with criteria of International Diabetic Federation (IDF). The prevalence of metabolic syndrome was 36.7%. The risk of metabolic syndrome detection (univariate analysis) increased with presence of obstetric history of HPT (odds ratio (OR) 2.64, 95% (CI) 1.25-5.62), family history of HPT (odds ratio (OR) 1.71 , 95% (CI) 1.13-2.59) and obesity (odds ratio (OR) 2.59, 95% (CI) 1.08-6.23 ), and the usage of contraception (odds ratio (OR) 1.56, 95% (CI)1.02-2.42). Screening for metabolic syndrome in postmenopausal women is important for early identification and aggressive management.