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Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma
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The publication is a progress report of the understanding of secondary brain damage from head injury and cerebral ischemia. The spectrum reaches from the molecular- and cell biological level up to the complex issues of clinical management. Specific topics on cerebral ischemia are concerned with apoptosis, inflammation, acidosis, cellular Ca2+-overflow, the role of the stimulatory input for maintenance of functional competence in stroke, effects of brain grafting in infarction, and the current state of glutamate antagonization or reestablishment of cerebral blood flow by thrombolysis, among others. Novel data on head injury relate with the cell biological response of the damaged axon, the activation of microglia, the role of b-amyloid precursor protein in the later development of Alzheimer s disease, and the current understanding of neuronal regeneration. Aspects of management and treatment have a spectrum from novel antioxidants to international consensus efforts.
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