Lead Generation Approaches in Drug Discovery

An integrated overview of modern approaches to lead discovery§Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including:§The evolution of the lead discovery process, key concepts, current challenges, and future directions§Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process§Knowledge-based in silico or "virtual" screening§Theory and practice of the fragment-based approach to lead discovery§The opportunities and challenges presented by multi-target drug discovery (MTDD)§De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo-designed molecules§The impact of natural products on drug discovery, and potential of natural product-like compounds for exploring regions of biologically relevant chemical space§Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery§The utility of parallel synthesis and purification in lead discovery§With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.This resource provides an integrated and comprehensive overview of modern approaches to drug lead discovery. Each chapter in this book reviews the theoretical background and application of a key technology in drug discovery, complemented by relevant case studies. The coverage includes the key approaches for drug design and discovery - high-throughput screening, fragment screening, multi-target drugs, de novo design, ADMET, natural products. This cutting-edge reference helps medicinal chemists in biotech, pharmaceutical, and other research contexts consider all possible avenues in starting their drug research programs.