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HIV Diversity and Antiretroviral Resistance
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The human immunodeficiency virus (HIV) already§infected more than 30 million people worldwide is§among the most genetically variable human viruses and§is characterized by high rates of replication,§mutation, and recombination, presenting a§nerve-racking challenge to disease treatment and the§development of an efficacious vaccine that can§eradicate the virus. As many countries begin to§introduce large scale access to anti-HIV drugs§(highly active antiretroviral therapy, HAART) to§control the disease, ongoing surveillance for HIV§drug resistant variants in patients beginning initial§antiretroviral or experiencing antiretroviral regimen§failure is essential in monitoring treatment§programs. In this book, genetic diversity of HIV and§the profiles of genetic mutations associated with§drug resistance in HIV-infected populations in the§Malaysian capital of Kuala Lumpur were assessed,§leading to the discovery of a novel recombinant virus
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