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Genome Mapping and Genomics in Human and Non-Human Primates
Angličtina
467 b
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This book provides an introduction to the latest gene mapping techniques. It especially highlights the advances made in large-scale genomic sequencing, thanks to which we can now explain complex phenotypes such as multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes and obesity), anatomic characteristics (e.g., the craniofacial complex) and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior). Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure and a discussion of the Human Genome Project. Further aspects include statistical genetics and genetic epidemiologic techniques using data from human and non-human primates, with the aim being to decipher the genetic architecture of normal and disease-related complex phenotypes. Examples of successful applications of genomic methods to traits of particular interest in biomedical research and evolutionary biology round out the volume.§
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