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Gamma-Secretase and Its Substrates A Bioinformatics Approach
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Gamma-secretase is an enzymatic complex critical to§amyloid formation and other important§pathophysiological processes. Non-specific§gamma-secretase inhibitors are not ideal for§intervention of familial Alzheimer s disease. Also§gamma-secretase cleaves a variety of substrates. But§different sites are cleaved even in a single§substrate and no consensus sequence for cleavage by§gamma-secretase is identified. We hypothesize that§consensus compositional sequence in components of§gamma-secretase and its substrates should exist§during gamma-secretase regulation and specific§gammasecretase inhibitor based on such consensus§sequence may act as a therapeutic intervention for§familial Alzheimer s disease. There are two stages in§our research. First, We find the candidates by the§methods of bioinformatics. Then, we use the§traditional biological methods to verify the critical§role of the candidates including the protein§purification, recognition, and functional domain§interaction. The book can serve as reference for§computational biology-oriented professionals in§advanced research development.
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