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This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:§§· Evolution and detection of endogenous ADP-ribosylation§§· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)§§· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)§§The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.§§