Conformational Concept For Synthetic Chemist's Use: Principles And In Lab Exploitation

Traditionally, most synthetic organic chemists are distanced from computational chemistry. However, in the last decade, very user-friendly calculation packages have permitted a reliable conformational analysis to be performed by an advanced experimentalist. This book will fill the gap between conformational theory and its benefit for organic chemists. It combines an analytic overview of conformational concepts and systemized practical instructions on how to carry out conformational studies in an organic laboratory equipped with high-performance PCs.Conformational concepts will be presented briefly for a sound theoretical understanding. The monograph will describe conformational studies as a readily available and powerful instrument for synthetic chemists. Emphasis will be given to computational methods (innovative methodology in the research arsenal of synthetic chemists), although experimental methods (mostly nuclear magnetic resonance) will also be included. Some often misunderstood facts will be explained clearly. Thus, this book will supply synthetic chemists with a guide for performing conformational studies by themselves, and thus for predicting or, at least, explaining the regioselectivity and stereoselectivity of their own reactions.