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Clathrin-Independent Endocytosis of ErbB2 in Human Breast Cancer Cells
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Endocytosis is an essential cellular process required§for functions including nutrient uptake, membrane§recycling, and signal transduction. In comparison to§the clathrin-mediated pathway, clathrin-independent§pathways are poorly understood. New work is now§beginning to reveal a picture of multiple§non-clathrin pathways. Findings presented in this§book identify that ErbB2 is internalized through a§non-clathrin pathway in geldanamycin-treated SKBr3§human breast cancer cells. ErbB2 internalization§resembled a newly described non-clathrin pathwaytermed the GEEC pathway, a pathway thought to be§specific for internalization of GPI-anchored§proteins. Suprisingly, ErbB2 and GPI-anchored§proteins also co-localized with chimeric fusion§proteins containing transmembrane domains, proteins§expected to be excluded from the GEEC pathway. §Combined with other data from the lab, these results§suggest that this pathway is not specific for§GPI-anchored proteins and may instead represent a§bulk internalization pathway.
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