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Introduces the reader to Circulating Tumor Cells (CTCs), their isolation method and analysis, and commercially available platforms§Presents the historical perspective and the overview of the field of circulating tumor cells (CTCs)§Discusses the state-of-art methods for CTC isolation, ranging from the macro- to micro-scale, from positive concentration to negative depletion, and from biological-property-enabled to physical-property-based approaches§Details commercially available CTC platforms§Describes post-isolation analysis and clinical translation§Provides a glossary of scientific terms related to CTCs