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This book constitutes the refereed proceedings of the 4th International Conference on Artificial Immune Systems, ICARIS 2005, held in Banff, Alberta, Canada, in August 2005. The 37 revised full papers presented were carefully reviewed and selected from 68 submissions. The papers are organized in topical sections on conceptual, formal, and theoretical frameworks, immunoinformatics, theoretical and experimental studies on artificial immune systems, and applications of artificial immune systems.