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Unlike traditional fixed clinical trials that cannot be altered once the study begins, adaptive designs allow the study design to be modified in response to the data being generated in the course of the trial. The newly developed web-based real-time data entry and recent advances in statistical methods have made it possible to perform real-time, adaptive clinical trials. Suitable for readers in academia, industry, and government involved in drug development, this up-to-date, easy-to-read book covers the essential aspects of adaptive clinical trials. It discusses the design, conduct, and execution of these trials.