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Ovine contribute to the attainment of food-self sufficiency especially in protein requirements for the growing human population and to increase export earnings. However, factors such as poor state of health, inadequate nutrition, traditional production system, low genetic potential, and the lack of in puts are presumed to be the causes for low productivity. Epidemiological survey and strain characterizations of ovine pasteurellosis were carried out to identify, estimate, and, characterize pasteurella species. Consequently, M.haemolytica A1 and A6 were found to be the prominent strains and therefore, could be recommended as candidates for the preparation of a vaccine against ovine pasteurellosis. This would probably promote the efficacy of the current ovine pasteurellosis vaccine production. Elucidation of these will, nevertheless, advance the epidemiology of this disease and its cost-effectiveness in its management. This book, therefore, is of particular interest to researchers, vaccine institutions, sheep ranch owners and policy makers, to emphasis and work towards the vaccine development and quality control of small ruminant vaccine.