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Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis, and prognosis. It explains how molecular tests are utilized in the treatment of patients in personalized medicine and highlights new technologies and approaches of applied molecular pathology and how discovery-based research yields new and useful biomarkers and tests. Basic scientists, clinical scientists, and physicians have a need for up-to-date information on the current understanding of the molecular basis of human disease and how we harness the molecular features of disease for practical molecular testing. It is essential to stay up-to-date with the new molecular diagnostics in this changing field. This field has become critically important in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis, and pathophysiology of human disease. This is a must-have resource! Includes new material covering mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more! Provide insight as to the value of the molecular test in comparison to traditional methods, which includes speed, precision, sensitivity, and clinical impact for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease