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This handbook consists of actual case material with a presentation of the clinical and laboratory data, an extensive discussion and analysis of the differential diagnoses, and a description of the pathology findings. The material, in problem-based format, includes 34 cases, more than 90 illustrations, an anatomy glossary, and laboratory normal values. It is intended for use by medical students in problem-based curricula, but is presented with sufficient sophistication to be useful to residents in pathology and internal medicine, and to pathologists and cardiologists. The book covers the entire spectrum of cardiovascular disease and may be unique, as there is nothing known to the authors that is comparable.